Table 1.

Cyclic AMP accumulation (pmol/10⁶ cells) in HEK 293 cells transiently expressing full-length (A_2B) and truncated versions (A_2B-316, A_2B-ΔC-tail) of the A_2B adenosine receptor

	Controla	A2B	A2B-316	A2B-ΔC-tail
Basalb	0.58 + 0.03c	1.42 ± 0.08 (p < 0.01)d	1.38 ± 0.22 (p < 0.01)	0.53 ± 0.02 (p > 0.05)
Forskolin	2.32 ± 0.12	9.72 ± 0.34 (p < 0.01)	10.92 ± 0.72 (p < 0.01)	2.22 ± 0.23 (p > 0.05)
NECA	1.59 ± 0.04	2.35 ± 0.05 (p < 0.05)	5.31 ± 0.37 (p < 0.01)	1.73 ± 0.05 (p > 0.05)

^aMock-transfected HEK 293 cells were used as a control

^bCyclic AMP accumulation was measured in the absence (basal), or in the presence of 1 μM forskolin or 10 μM NECA

^cData are results from four experiments presented as mean ± SEM

^dp values in parentheses are results of one-way analysis of variance within each group (basal, forskolin, NECA) with Dunnett's post-tests versus corresponding controls