Table 2.
Changes in hemodynamic, oxygen transport, and tonometric variables as mean arterial pressure was increased from 65 mmHg to 85 mmHg with norepinephrine
| Mean arterial blood pressure | ANOVA | Linear trend | |||
| 65 mmHg | 75 mmHg | 85 mmHg | P | P | |
| Norepinephrine doses (μg/kg/min) | 0.48 ± 0.43 | 0.65 ± 0.68* | 0.74 ± 0.67* | < 0.0001 | < 0.0001 |
| Heart rate (beats/min) | 94 ± 21 | 92 ± 18 | 93 ± 18 | 0.59 | 0.43 |
| Mean arterial blood pressure (mmHg) | 65 ± 2 | 76 ± 2* | 85 ± 2* | < 0.0001 | < 0.0001 |
| Mean pulmonary artery pressure (mmHg) | 28 ± 7 | 30 ± 7* | 30 ± 7* | < 0.0001 | < 0.0001 |
| Pulmonary artery occlusion pressure (mmHg) | 14 ± 4 | 15 ± 4 | 16 ± 4 | 0.06 | 0.02 |
| Central venous pressure (mmHg) | 11 ± 4 | 12 ± 4 | 12 ± 4 | 0.18 | 0.47 |
| Cardiac index (l/min/m2) | 2.98 ± 0.99 | 3.11 ± 1.07 | 3.23 ± 1.02* | 0.0002 | < 0.0001 |
| Oxygen transport (ml/min/m2) | 366 ± 137 | 379 ± 145 | 383 ± 166 | 0.53 | 0.28 |
| Oxygen consumption (ml/min/m2) | 100 ± 33 | 91 ± 31 | 90 ± 40 | 0.61 | 0.63 |
| Intramucosal-arterial pCO2 (mmHg) | 15 ± 15 | 16 ± 18* | 16 ± 18 | 0.03 | 0.06 |
* P < 0.05 vs. basal (Dunnett post hoc test after repeated measures ANOVA).
ANOVA = analysis of variance; pCO2 = partial pressure of carbon dioxide.