Table 2.
PROGRESS clinical characteristics
| Variable |
DrotAA n = 882 |
Non-DrotAA n = 11,610 |
Total n = 12,492 |
P value |
| Medical/Surgical Status, n (%): | <0.001 | |||
| Medical | 540 (61.2) | 7232 (62.3) | 7772 (62.2) | |
| Surgical – Elective | 127 (14.4) | 1205 (10.4) | 1332 (10.7) | |
| Surgical – Emergency | 215 (24.4) | 3173 (27.3) | 3388 (27.1) | |
| SIRS criteria met, n (%): | (n = 858) | (n = 11,241) | (n = 12099) | <0.001 |
| 0 | 2 (0.2) | 29 (0.3) | 31 (0.3) | |
| 1 | 5 (0.6) | 188 (1.7) | 193 (1.6) | |
| 2 | 57 (6.6) | 1198 (10.7) | 1255 (10.4) | |
| 3 | 268 (31.2) | 4063 (36.1) | 4331 (35.8) | |
| 4 | 526 (61.3) | 5763 (51.3) | 6289 (52.0) | |
| Source of infection, n (%): | (n = 856) | (n = 11,260) | (n = 12,116) | <0.001 |
| Community acquired | 529 (61.8) | 6033 (53.6) | 6562 (54.2) | |
| Nosocomial – hospital acquired | 217 (25.4) | 3172 (28.2) | 3389 (28.0) | |
| Nosocomial – ICU acquired | 110 (12.9) | 2055 (18.3) | 2165 (17.9) | |
| Type of infection, n (%): | (n = 675) | (n = 8380) | (n = 9055) | |
| Gram negative | 392 (58.1) | 4795 (57.2) | 5187 (57.3) | 0.67 |
| (n = 681) | (n = 8396) | (n = 9077) | ||
| Gram positive | 371 (54.5) | 3668 (43.7) | 4039 (44.5) | <0.001 |
| (n = 682) | (n = 8678) | (n = 9360) | ||
| Fungal | 103 (15.1) | 986 (11.4) | 1089 (11.6) | 0.003 |
| Primary site of infection, n (%): | (n = 861) | (n = 11,301) | (n = 12,162) | 0.35 |
| Abdominopelvic | 227 (26.4) | 2642 (23.4) | 2869 (23.6) | |
| Bone or joint | 13 (1.5) | 160 (1.4) | 173 (1.4) | |
| Hematogenous | 59 (6.9) | 738 (6.5) | 797 (6.6) | |
| Indwelling catheter-dialysis access | 3 (0.3) | 79 (0.7) | 82 (0.7) | |
| Indwelling catheter-vascular access | 11 (1.3) | 163 (1.4) | 174 (1.4) | |
| Lung | 366 (42.5) | 5282 (46.7) | 5648 (46.4) | |
| Meninges | 12 (1.4) | 169 (1.5) | 181 (1.5) | |
| Skin or skin structure | 44 (5.1) | 586 (5.2) | 630 (5.2) | |
| Urinary tract | 71 (8.2) | 887 (7.8) | 958 (7.9) | |
| Other | 55 (6.4) | 595 (5.3) | 650 (5.3) |
DrotAA = drotrecogin alfa (activated); ICU = intensive care unit; PROGRESS = Promoting Global Research Excellence in Severe Sepsis; SIRS = Systemic Inflammatory Response Syndrome.