Table 5.

Clinical and virologic differences between hepatitis B virus genotypes A and D

	Genotype A	Genotype D
Clinical differences
Acute hepatitis	Less	More
Chronic hepatitis	More	Less
Reactivation after HBeAg seroconversion	Less	More
Histologic activity	Lower	Higher
Clinical outcome (cirrhosis and hepatocellular carcinoma)	Better	Worse
Recurrence after liver transplantation	Lower	Higher
Virologic differences
Frequency of precore A1896 mutation	Lower	Higher
Frequency of basal core promoter T1762/A1764 mutation	Higher	Lower