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. Author manuscript; available in PMC: 2009 Jul 28.
Published in final edited form as: Exp Hematol. 2007 Feb;35(2):214–220. doi: 10.1016/j.exphem.2006.10.001

Table 3.

Relative repopulating ability to reconstitute bone marrow

Relative repopulating abilities of donor ST-HSC Relative repopulating abilities of donor LT-HSC
Donor genotype
B6 +/+ 100 100
W-v/+ 48 19
W-41/+ 60 40
W-41/W-41 34 18
W-42/+ 41 26

On the B6 strain background, Kit mutant and +/+ donors were Ly5.2, and competitors were B6.Ly5.1; all were 2–3 month old males. Mixtures of 6x106 donor and 6x106 competitor BMCs were iv injected into each lethally irradiated B6 recipient, whose bone marrow was analyzed at 1 and 4-months post-transplantation. Relative repopulating abilities of the Kit mutants and the normal control were calculated from mean percentages of donor KSL cells as RU values; values are presented as percentages of normal repopulating ability (RU donor x 100/RU normal control). All mutant values are significantly different from normal control values (P < 0.001), with 6 donors analyzed for each genotype at each time point.