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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Neurobiol Aging. 2008 Feb 20;30(7):1061–1068. doi: 10.1016/j.neurobiolaging.2007.10.009

Figure 2.

Figure 2

The cholinesterase inhibitor phenserine tartrate (PT) enhances LTP in wild-type mice, but inhibits LTP in PS1KI mice. A. The normalized EPSP slopes in slices from wild-type (WT) and PS1KI mice that had been treated with 5 μM PT or vehicle. Values are the mean and SEM (6-8 slices from 5-6 mice). *p< 0.05 compared to the PS1KI value, **p< 0.01 compared to the WT value). B. Paired pulse facilitation (PPF) analysis showing the S1/S2 ratios for increasing stimulation interpulse intervals in slices from WT and PS1KI mice (8-10 slices from 5-6 mice). *p< 0.05 compared to the PS1KI value. C. PPF analysis in the presence of 50 μM carbachol.