Table 1.
Model cell parameters altered to construct four cell types
| Vhalf K+dr (mV) | gKdr (S/cm2) | gNa (S/cm2) | gKa (S/cm2) | gh (mS/cm2) | EK (mV) | ENa (mV) | Eh (mV) | |
|---|---|---|---|---|---|---|---|---|
| Cell A | 13 | 0.2 | 0.3 | 0.048 | 0.5 | −90 | 55 | −30 |
| Cell B | 13 | 0.5 | 0.5 | 0.048 | 0.1 | −77 | 50 | 0 |
| Cell C | 0 | 0.08 | 0.3 | 0.048 | 0.75 | −90 | 55 | −30 |
| Cell D | 0 | 0.7 | 1.5 | 0.03 | 0.5 | −77 | 50 | 0 |
Changes in the steady-state, half-activation of the Kdr current (Vhalf K+dr) eliminated low-frequency firing at threshold for type II-like cells. Changes in maximal conductances of Na+ (gNa) and K+-dr (gKdr) currents promoted spiking. Changes in maximal conductances of K+ A-type (gKa), and h (gh) currents modulated resting membrane potential and rheobase current.