Table 1.
General baseline characteristics in groups defined by baseline eGFR.
| Characteristic | Cat. A–D | Category A eGFR≥90 mL/min per 1.73 m2 |
Category B 60≤eGFR<90 mL/min per 1.73 m2 |
Category C 30≤eGFR<60 mL/min per 1.73 m2 |
p-value |
|---|---|---|---|---|---|
| N | 403 | 67 | 160 | 155 | |
| eGFR, mL/min per 1.73 m2 | 65.5±1.2 | 104.5±2.1 | 72.9±0.6 | 46.2±0.7 | |
| CRT, % | 52.4 | 56.7 | 51.3 | 52.9 | 0.75 |
| Age, years | 64±1 | 55±1b,c | 62±1a,c | 68±1a,b | <0.001 |
| Male sex, % | 67.7 | 64.2 | 66.9 | 71.6 | 0.48 |
| Ischemic etiology, % | 53.8 | 37.3c | 48.8c | 65.2a,b | <0.001 |
| Body mass index, kg/m2 | 28.7±0.4 | 29.4±0.81 | 29.8±0.7c | 27.2±0.5b | 0.008 |
| Diabetes, % | 31.8 | 34.3 | 27.5 | 32.9 | 0.47 |
| Hemoglobin, g/dL | 13.1±0.1 | 13.4±0.2 | 13.4±0.1c | 12.9±0.1b | 0.006 |
| Serum creatinine, mg/dL | 1.26±0.02 | 0.79±0.02b,c | 1.03±0.01a,c | 1.56±0.02a,b | <0.001 |
| Blood urea nitrogen, mg/dL | 29.6±0.9 | 17.9±1.2b,c | 23.2±.1.0a,c | 38.2±1.5a,b | <0.001 |
| NYHA class III/IV, % | 92/8 | 97/3 | 95/5c | 87/14b | 0.005 |
| 6-minute hallwalk, m | 303±4 | 304±11 | 306±7 | 303±7 | 0.99 |
| Mean blood pressure, mmHg | 84±1 | 86±1c | 85±1 | 82±1a | 0.013 |
| LV ejection fraction, % | 24±1 | 22±1 | 25±1 | 24±1 | 0.09 |
| LV end diastolic volume, mL | 301±6 | 310±16 | 302±11 | 297±10 | 0.77 |
| LV end systolic volume, mL | 234±6 | 247±15 | 234±10 | 230±9 | 0.62 |
| Cardiac index, L/min per m2 (VTI) | 1.57±0.03 | 1.65±0.09 | 1.58±0.05 | 1.52±0.05 | 0.30 |
| MR jet area, cm2 | 7.47±0.34 | 5.0±0.6c | 6.3±0.4c | 9.2±0.6a,b | <0.001 |
| LV mass index, g/m2 | 182±3 | 181±6 | 180±5 | 182±4 | 0.97 |
| ANP, pg/mL | 86 (38/171) | 47 (28/98)c | 75 (31/137)c | 119 (48/201)a,b | <0.001 |
| BNP, pg/mL | 456 (141/1172) | 208 (56/490)c | 448 (130/1007)c | 661 (204/1633)a,b | <0.001 |
| PRA, ng·mL−1·h−1 | 10.9 (2.9/18.6) | 8.3 (2.8/14.1) | 10.0 (2.0/19.6) | 12.4 (4.1/19.1) | 0.08 |
| Aldosterone, ng/dL | 9.9 (5.5/18.7) | 7.4 (4.2/11.6)c | 10.0 (5.2/19.0) | 10.9 (6.3/20.4)a | 0.004 |
| Norepinephrine, pg/mL | 391 (261/587) | 359 (176/495)c | 344 (243/501)c | 456 (304/683)a,b | <0.001 |
| Big Endothelin, pg/mL | 9.9 (5.9/15.9) | 7.0 (4.4/12.7)c | 8.0 (5.8/12.1)c | 12.4 (7.7/22.1)a,b | <0.001 |
| Diuretic, % | 94 | 90c | 92 | 97a | 0.039 |
| ACEi/ ARB, % | 93 | 97 | 93 | 92 | 0.41 |
| Betablocker, % | 60 | 70 | 63 | 54 | 0.06 |
Values are mean±SEM, percentage, or median (25th/75th percentile). P-value is for comparison of Categories A–C.
a
p<0.05 vs. group A
b
p<0.05 vs. group B
c
p<0.05 vs. group C.
ANP, atrial natriuretic , BNP, B-type natriuretic peptide, ACEi/ARB, angiotensin converting enzyme inhibitor/angiotensin receptor blocker, CRT, cardiac resynchronization therapy, eGFR, estimated glomerular filtration rate. LV, left ventricular, MR mitral regurgitation, NYNA New York Heart Association, PRA, plasma renin activity..