Table 2.
Mean changes of functional parameters from baseline to 6 months in categories of baseline eGFR.
| Category A eGFR≥90 mL/min per 1.73 m2 |
p | Category B 60≤eGFR<90 mL/min per 1.73 m2 |
p | Category C 30≤eGFR<60 mL/min per 1.73 m2 |
p | ||
|---|---|---|---|---|---|---|---|
| N | Control | 29 | 78 | 73 | |||
| CRT | 38 | 82 | 82 | ||||
| NYHA class | Control | −0.41±0.15 (29) | 0.006 | −0.39±0.07 (75) | <0.001 | −0.44±0.08 (71) | <0.001 |
| CRT | −0.86±0.10 (37) | −0.83±0.09 (81) | −0.89±0.08 (80) | ||||
| 6-minute hallwalk, | Control | +33±21 (29) | 0.16 | +17±11 (76) | 0.12 | −6±12 (71) | 0.01 |
| m | CRT | +40±18 (38) | +37±9 (82) | +13±12 (81) | |||
| Mean blood pressure, | Control | +1.0±2.5 | 0.06 | +1.1±1.5 | 0.43 | −0.7±1.3 | 0.02 |
| mmHg | CRT | −4.5±1.8 | +2.7±1.5 | +3.9±1.4 | |||
| LV ejection | Control | +2.3±1.5 (25) | 0.016 | 0.0±0.9 (55) | <0.001 | 0.0±0.8 (51) | 0.001 |
| fraction, % | CRT | +7.0±1.2 (26) | +5.7±1.1 (62) | +4.4±0.9 (60) | |||
| LV end diastolic | Control | −8±11 (25) | 0.010 | +15±7 (55) | <0.001 | +11±9 (51) | 0.003 |
| volume, mL | CRT | −52±12 (26) | −38±7 (62) | −30±10 (60) | |||
| LV end systolic | Control | −12±12 (25) | 0.012 | +13±6 (55) | <0.001 | +8±8 (51) | 0.002 |
| volume, mL | CRT | −53±10 (26) | −40±7 (62) | −30±9 (60) | |||
| Cardiac index, | Control | −0.16±0.14 (18) | 0.45 | −0.08±0.09 (40) | 0.074 | 0.00±0.09 (42) | 0.54 |
| L/min per m2 (VTI) | CRT | 0.00±0.14 (24) | 0.14±0.08 (49) | 0.07±0.07 (53) | |||
| Mitral regurgitation | Control | +0.6±1.5 (21) | 0.045 | −0.5±0.5 (47) | 0.003 | −0.7±0.8 (41) | 0.009 |
| jet area, cm2 | CRT | −2.7±0.6 (22) | −3.1±0.7 (45) | −3.7±0.7 (43) | |||
| LV mass, | Control | −11±10 (19) | 0.90 | +14±10 (39) | 0.162 | +19±9 (39) | 0.006 |
| g | CRT | −8±16 (22) | −6±10 (51) | −23±11 (44) | |||
| Serum creatinine | Control | +0.09±0.03 (29) | 0.48 | +0.05±0.03 (78) | 0.59 | +0.16±0.05 (73) | 0.001 |
| mg/dL | CRT | +0.13±0.04 (38) | +0.07±0.03 (82) | −0.04±0.03 (82) | |||
| Atrial natriuretic | Control | +8 (−34/85) | 0.54 | −3 (−69/61) | 0.67 | −2 (−77/63) | 0.02 |
| peptide, pg/mL | CRT | +6 (−30/23) | −8 (−50/29) | −14 (−88/22) | |||
| B-type natriuretic | Control | 0 (−385/238) | 0.45 | −9 (−383/225) | 0.16 | −268 (−1035/52) | 0.61 |
| peptide, pg/mL | CRT | −33 (−176/34) | −166 (−475/86) | −125 (−792/193) |
Values are mean±SEM or median (25th/75th percentile. P-values are Control vs. CRT in the respective category. eGFR, estimated glomerular filtration rate, LV, left ventricular, NYHA, New York Heart Association.