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. 2009 Aug;134(2):151–164. doi: 10.1085/jgp.200910240

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© 2009 Martínez-François et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Effect of S4 mutations on voltage gating induced by the E363Q mutation. (A–C) Macroscopic currents recorded in 2 mM cGMP from E363Q mutant channels containing an additional substitution in S4: R272T (R2T; A), R275Q (R3Q; B), or R278Q (R4Q; C). (D) G-V curves (mean ± SEM; n = 3–8) for the E363Q mutants without (open squares) or with an additional S4 substitution: R272T (filled circles), R275Q (open triangles), or R278Q (filled inverted triangles). The four curves are superimposed.