Table 1.

Proteasome inhibitors decrease virus infectivity

Parallel cultures of HIV-1_NL4–3-infected A3.01 cells either were left untreated or were incubated with 40 μM zLLL for 1 or 6 h. Cells were washed, and incubation in the presence or absence of zLLL was continued for another 4.5 h as indicated in the time scheme on top. Virus-containing medium was collected, and CA antigen was quantitated by ELISA. Virus titer was determined by endpoint dilution on C8166 cells. The specific infectivity was calculated as infectious titer per nanogram of CA and expressed in percent of the untreated sample.