Skip to main content
. Author manuscript; available in PMC: 2009 Jul 29.
Published in final edited form as: Muscle Nerve. 2009 Mar;39(3):283–296. doi: 10.1002/mus.21244

FIGURE 3.

FIGURE 3

The follistatin gene consists of six exons. Alternative splicing generates two isoforms, FS317 and FS344. Alternative splicing occurs at the 3′ end of the gene between exon 5 and exon 6. Splicing out of intron 5 generates a stop codon immediately following the last amino acid of exon 5, and leads to the termination of the coding sequence for FS317. An alternative splice site results in the inclusion of exon 6 and generates FS344. After translation and prior to activation, follistatin undergoes further posttranslational modification by cleavage of the 29 amino acid signal peptide. This results in polypeptides FS315 (long-isoform from FS344) and FS288 (short-isoform from FS317).