. Author manuscript; available in PMC: 2009 Oct 23.

Published in final edited form as: J Med Chem. 2008 Sep 25;51(20):6421–6431. doi: 10.1021/jm800648y

Table 2.

Water solubility of indirubin salts and calculated physicochemical properties pKa and logD at pH 7.4 of corresponding bases.

No.	Solubility (g/l)	pKa	LogD
6BIO	< 0.005	-	2.59

16	0.141	8.59	1.69
17	0.192	9.38	1.19
18	0.195	9.18	1.16
21	1.45	7.48	1.79
22	1.61	8.85	−0.87
23	1.50	7.65	1.74
24	1.14	7.65	1.41
25	0.57	7.47	1.90
26	4.253	7.58	1.46