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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Hepatology. 2008 Dec;48(6):1810–1820. doi: 10.1002/hep.22569

Figure 4. Hepatic mRNA and protein expression of lipogenic genes in human subjects with NASH and matched controls.

Figure 4

mRNA levels of hepatic lipogenic genes were expressed as relative fold change from a single human liver sample used as the internal calibrator across all RT-PCR experiments. Overall, the hepatic mRNA levels of FAS, SREBP-1c and HMGCR were increased significantly in subjects with NASH compared to controls (p< 0.05), while the hepatic mRNA level of SREBP-2 was not different between the two groups. As shown in panels b and c, SREBP-2, HMGCR, SREBP-1c and FAS protein were increased in NASH subjects (p< 0.02 for SREBP-2, p=ns for the rest).