Table 3.
HRs for Disease-Free Survival and Overall Survival by CRP and SAA Tertiles, Excluding Individuals With Self-Reported Cardiovascular Events or In Situ Disease Stage
| Tertile | Excluding Participants Reporting Cardiovascular Events* |
Excluding Participants With In Situ Disease† |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of Events | No. of Participants | HR | 95% CI | P (trend) | No. of Events | No. of Participants | HR | 95% CI | P (trend) | |
| Overall survival‡ | 75 | 697 | 80 | 565 | ||||||
| CRP, mg/L | ||||||||||
| ≤ 1.2 | 22 | 253 | 1.00 | Reference | 23 | 203 | 1.00 | Reference | ||
| 1.3-3.8 | 20 | 229 | 0.97 | 0.50 to 1.89 | 19 | 181 | 0.85 | 0.44 to 1.64 | ||
| ≥ 3.9 | 33 | 215 | 2.32 | 1.22 to 4.39 | .006 | 38 | 181 | 1.96 | 1.07 to 3.61 | .02 |
| SAA, mg/L | ||||||||||
| ≤ 4.2 | 16 | 248 | 1.00 | Reference | 16 | 189 | 1.00 | Reference | ||
| 4.3-8.0 | 17 | 225 | 1.00 | 0.49 to 2.05 | 18 | 190 | 0.98 | 0.48 to 1.98 | ||
| ≥ 8.1 | 42 | 224 | 3.32 | 1.78 to 6.17 | .0001 | 46 | 186 | 2.88 | 1.54 to 5.37 | .0002 |
| lnCRP | 75 | 697 | 1.43 | 1.14 to 1.79 | 47 | 565 | 1.24 | 1.01 to 1.54 | ||
| lnSAA | 75 | 697 | 1.86 | 1.41 to 2.45 | 47 | 565 | 1.37 | 1.05 to 1.79 | ||
| Disease-free survival§ | 83 | 692 | 77 | 559 | ||||||
| CRP, mg/L | ||||||||||
| ≤ 1.2 | 22 | 253 | 1.00 | Reference | 23 | 203 | 1.00 | Reference | ||
| 1.3-3.8 | 29 | 228 | 1.54 | 0.84 to 2.81 | 27 | 180 | 1.40 | 0.76 to 2.57 | ||
| ≥ 3.9 | 32 | 211 | 1.91 | 1.01 to 3.61 | .05 | 27 | 176 | 1.34 | 0.70 to 2.57 | .40 |
| SAA, mg/L | ||||||||||
| ≤ 4.2 | 24 | 247 | 1.00 | Reference | 22 | 188 | 1.00 | Reference | ||
| 4.3-8.0 | 21 | 224 | 0.98 | 0.53 to 1.80 | 21 | 189 | 1.02 | 0.55 to 1.90 | ||
| ≥ 8.1 | 38 | 221 | 1.75 | 1.00 to 3.07 | .04 | 34 | 182 | 1.58 | 0.87 to 2.86 | .12 |
| lnCRP | 83 | 692 | 1.23 | 0.99 to 1.53 | 77 | 559 | 1.05 | 0.86 to 1.31 | ||
| lnSAA | 83 | 692 | 1.46 | 1.09 to 1.95 | 77 | 559 | 1.16 | 0.87 to 1.53 | ||
Abbreviations: HR, hazard ratio; CRP, C-reactive protein; SAA, serum amyloid A; BMI, body mass index.
*
Adjusted for age (continuous), disease stage, race/study site, BMI (continuous), and estrogen receptor/progesterone receptor status.
†
Adjusted for age (continuous), disease stage, race/study site, BMI (continuous), estrogen receptor/progesterone receptor status, and self-reported history of cardiovascular events (heart failure and myocardial infarction).
‡
Data on overall survival collected through April 30, 2008.
§
Data on disease-free survival collected through September 30, 2004.