Table 5.
Genotype Profiles in Japanese and US Patients on LC00-03 and S0003
| Polymorphism by Trial Location | No. of Patients |
P | ||
|---|---|---|---|---|
| Com | Het | Var | ||
| CYP3A4*1B | ||||
| Japan | 73 | 0 | 0 | .01 |
| United States | 64 | 4 | 3 | |
| CYP3A5*C | ||||
| Japan | 7 | 16 | 50 | .03 |
| United States | 3 | 7 | 66 | |
| CYP2C8 (R139K) | ||||
| Japan | 69 | 2 | 0 | .01 |
| United States | 57 | 7 | 5 | |
| ABCB1 (3435C→T) | ||||
| Japan | 33 | 21 | 17 | .11 |
| United States | 24 | 23 | 29 | |
| NR1l2 (206 deletion) | ||||
| Japan | 51 | 19 | 5 | .25 |
| United States | 40 | 25 | 8 | |
| ERCC1 (118) | ||||
| Japan | 8 | 27 | 43 | < .0001 |
| United States | 23 | 33 | 19 | |
| ERCC2 (K751Q) | ||||
| Japan | 73 | 1 | 0 | < .001 |
| United States | 37 | 27 | 8 | |
NOTE. LC00-03 is the trial in Japan; S0003 is the trial in the United States. Fisher's exact test was used to determine whether allele distributions were different between the populations.
Abbreviations: Com, common allele; Het, heterozygous allele; Var, variant allele.