Table 6.

Cox Model to Compare Outcomes by Polymorphism

Outcome by Polymorphism	Analyses
	Comparison	HR	95% CI	P
ABCB1 3425
Overall survival	Com v Het/Var (CC v CT/TT)	1.09	0.71 to 1.67	.69
PFS		1.04	0.70 to 1.56	.82
Response		0.97	0.39 to 2.38	1.00
Neutropenia		0.54	0.22 to 1.30	.19
CYP2C8 R139K
Overall survival	Com v Het/Var (GG v GA/AA)	1.09	0.61 to 1.96	.76
PFS		1.12	0.63 to 2.00	.69
Response		1.92	0.46 to 11.11	.51
Neutropenia		1.30	0.35 to 5.00	.87
CYP3A4*1B
Overall survival	Com v Het/Var (AA v AG/GG)	0.74	0.32 to 1.72	.48
PFS		0.36	0.14 to 0.94	.04
Response		0.63	0.10 to 4.76	.84
Neutropenia		0.44	0.04 to 2.94	.58
CYP3A5*3C
Overall survival	Com/Het v Var (AA/AG v GG)	1.64	0.95 to 2.86	.07
PFS		1.56	0.93 to 2.63	.09
Response		1.61	0.53 to 4.76	.47
Neutropenia		1.30	0.44 to 3.85	.78
ERCC1 (118)
Overall survival	TT v TC/CC	1.20	0.74 to 1.96	.45
PFS		1.11	0.69 to 1.82	.65
Response		1.45	0.48 to 4.17	.61
Neutropenia		0.57	0.20 to 1.61	.35
ERCC2 K751Q
Overall survival	Com v Het/Var (AA v AC/CC)	0.97	0.63 to 1.49	.89
PFS		0.85	0.55 to 1.30	.45
Response		0.33	0.13 to 0.83	.02
Neutropenia		0.75	0.30 to 1.85	.63
nr1I2-206 del
Overall survival	Com v Het/Var 206 deletion	0.82	0.53 to 1.25	.35
PFS		0.93	0.63 to 1.39	.75
Response		0.82	0.34 to 2.00	.77
Neutropenia		0.88	0.37 to 2.08	.90

Abbreviations: HR, hazard ratio; PFS, progression-free survival; Com, common allele; Het, heterozygous allele; Var, variant allele.