Figure 6.
Effect of anesthesia on motor function and tau solubility. A) Levels of sarkosyl-insoluble tau were plotted against levels of motor dysfunction (score) in 4- to 5-mo-old female JNPL3 mice (n=38, r2=0.69, P < 0.0001). B) Results from A stratified by categories. **P < 0.01 vs. Ctl; ANOVA with Neumans-Keuls post hoc test. C) Levels of insoluble tau, as detected by immunoblotting of brain stem proteins from 4.4-mo-old homozygous JNPL3 female control (Ctl; n=6), and mice examined 1 wk after a single exposure to isoflurane (Anes+1w; n=6). D) Motor dysfunction score of same group of mice as in C. E, F) motor dysfunction in homozygous male mice 8.2 mo old (E; Ctl, n=10; 4×Anes+1w, n=8), and 6.9 mo old (F; Ctl, n=12; 4×Anes+1w, n=9), respectively. Each point represents an individual mouse, with means ± se for each group. AU, arbitrary units. *P < 0.05 vs. Ctl; Mann-Whitney U test.