Figure 2.

MnSOD overexpression reduced amyloid plaque burden and microgliosis in Tg19959 mice. A, B) Amyloid plaques per 0.75 mm² (A) and percentage area covered by plaque (B) in Tg19959 mice and Tg19959-MnSOD littermates. At 4 mo of age, MnSOD overexpression reduced amyloid plaques in Tg19959 mouse brains. C) Representative photographs of amyloid plaques detected by Aβ42 antibody AB5078P. D) Percentage area covered by reactive microglia (mean±se). There was a trend toward a decrease of cortical microgliosis in Tg19959-MnSOD mice compared to Tg19959 littermates. *P < 0.05.