Figure 3.

MnSOD overexpression rescued spatial memory retention and restored synaptophysin levels in Tg19959 mice. A, B) Latency (A) and distance traveled (B) during the acquisition period over 5 d. Tg19959 and Tg19959-MnSOD mice were slower to learn than MnSOD and wild-type littermates. C) Percentage time spent in each quadrant during first 15 s of probe trial. Northwest quadrant was the target quadrant. Tg19959-MnSOD mice spent more time in the target quadrant compared to Tg19959 littermates. D) Western blot of synaptophysin, expressed as ratio of protein to α-tubulin. MnSOD overexpression restored synaptophysin levels in Tg19959 mice. Values are means ± se. *P < 0.05.