Table 4.
Bioinformatic indications of transcription factor activity
| p Value |
|||||
|---|---|---|---|---|---|
| TFBM | Ratio* | Univariate† | Random‡ | Sensitivity§ | |
| V$CP2_01 | 2.33 | 0.0156 | 0.0114 | 0.0943 | |
| V$TAL1BETAITF2_01 | 7.62 | 0.0166 | 0.0084 | 0.0922 | |
| V$NFY_C | 0.28 | 0.0223 | 0.0212 | 0.0485 | |
| V$CREB_Q4 | 0.45 | 0.0306 | 0.0334 | 0.0056 | |
| V$NFKB_Q6 | 2.54 | 0.0316 | 0.0232 | 0.0200 | |
| V$SREBP1_01 | 4.50 | 0.0391 | 0.0316 | 0.0759 | |
| V$COUP_01 | 4.85 | 0.0434 | 0.0360 | 0.0926 | |
| V$HSF2_01 | 0.71 | 0.0435 | 0.0460 | 0.0513 | |
| V$AP1FJ_Q2 | 0.65 | 0.0464 | 0.0484 | 0.0005 | |
| V$VJUN_01 | 0.20 | 0.0477 | 0.0512 | 0.0342 | |
*
TFBM prevalence in promoters of genes overexpressed in T lymphocytes from the low versus the high SES groups.
†
p Value from unequal variance Welch t test of TFBM prevalence.
‡
p Value based on 10 000 random samples of 60 human genes.
§
p Value for average over nine combinations of three promoter lengths (−300 bp, −600 bp, −1000 to +200 bp) and 3 TFBM detection stringencies (MatSim 0.80, 0.90, and 0.95)
SES, socioeconomic status; TFBM, transcription factor binding motif.