Table 2.

Correlation of microvessel density with clinicopathologic characteristics.

	CD34 area (mean, mm2)	CD34 intensity (mean × 105)	p value Statistical analysis
Lymphvascular invasion			Area: 0.927
Yes	0.015	249	Intensity: 0.783
No	0.011	194	Mann-Whitney test
Histologic grade
I	0.000	1.3	Area: 0.164
II	0.011	192	Intensity: 0.173
III	0.020	360	ANOVA test
Tumor size
<5 cm	0.008	154	Area: 0.276
5–10cm	0.018	314	Intensity: 0.329
>10 cm	0.012	200	ANOVA test
Etiology
Unknown	0.013	222	Area: 0.409
Alcohol	0.020	347	Intensity:0.459
HBV	0.007	111	ANOVA test
HCV	0.012	200

Although statistically not significant, the mean value of both CD34 area and intensity are higher in HCC with lymphvascular space invasion, high histological grade, intermediate tumor size, and the underlying etiology of hepatitis C and alcoholic steatohepatitis.