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. 2009 May 7;150(8):3699–3708. doi: 10.1210/en.2008-1667

Figure 3.

Figure 3

Kisspeptin acts on the hypothalamus to enhance LH surges in middle-aged rats. Data are means ± sem from OVX, estradiol, and progesterone replaced middle-aged control (MA; n = 4) and MA rats dialyzed with 10 nm Kp-10 alone (Kp-10; n = 4), with 10 nm Kp-10 and injected with vehicle (Veh; n = 4) or 10 nm Kp-10 and injected with 100 μg of the GnRH receptor antagonist cetrorelix both 24 h before and immediately before the progesterone injection (Kp-10 + cetrorelix; n = 4). Progesterone was injected at 0900 h (time 0). A, LH surges. B, Peak LH; F = 24.5, P < 0.0001. C, Total LH (AUC); F = 15.7, P < 0.001. D, LH surge onset (h relative to P injection). a, P < 0.001 vs. all other groups.