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HPA activation after acute citalopram is enhanced in female and R2KO mice. Administration of citalopram (CIT) produced enhanced corticosterone (CORT) levels in males (A) and females (B) relative to vehicle-treated mice (VEH). Female R2KO mice displayed a significantly enhanced citalopram effect compared with citalopram-treated WT females. Data are presented as mean values ± sem. *, Significant effect of genotype, P < 0.05; #, significant citalopram effect, P < 0.05.
