Table 5.

Changes in gene expression patterns of Krebs cycle and anaplerotic enzymes in lung tumor versus surrounding non-tumor tissues

	Fold ChangeA
GenesB	PC	GLS	IDH3	OGDH	SDH	FH	MDH2
AverageC	3.36	0.52	0.67	0.58	0.93	1.01	1.53
SD	1.13	0.16	0.13	0.09	0.19	0.23	0.29
p-valueD	0.03	0.04	0.05	0.01	0.24	0.31	0.04

^A Tumor over surrounding non-tumorous lung tissue

^B PC: pyruvate carboxylase; GLS: glutaminase; IDH: isocitrate dehydrogenase; OGDH: α-ketoglutarate dehydrogenase; FH: fumarate hydratase; MDH2: mitochondrial malate dehydrogenase

^C For patients #6–10

^D Obtained from paired t-test.