Table 1.
Pharmacokinetics of imatinib in Balb/C mice in the presence and absence of tariquidar
| Imatinib alone | Imatinib + Tariquidar | |||||
| Plasma | Mean | SD | Mean | SD | Fold Change | P-value |
| Cmax (ng/mL) | 5,710.5 | 1,472.3 | 6,813.2 | 1,547.9 | 1.19 | - |
| Tmax (hr) |
0.17 | - | 0.17 | - | - | - |
| AUC0–24 (hr*ng/mL) |
12,167.5 | - | 26,724.6 | - | 2.20 | 0.001 |
| Liver | Mean | SD | Mean | SD | Fold Change | P-value |
| Cmax (ng/g) |
26,279.7 | 4,560.2 | 46,139.1 | 11,000.6 | 1.76 | - |
| Tmax (hr) |
0.25 | - | 0.17 | - | - | - |
| AUC0–24 (hr*ng/g) |
68,330.8 | - | 153,209.2 | - | 2.24 | < 0.00001 |
| Brain | Mean | SD | Mean | SD | Fold Change | P-value |
| Cmax (ng/g) |
194.7 | 27.2 | 417.0 | 116.6 | 2.14 | - |
| Tmax (hr) |
2 | - | 2 | - | - | - |
| AUC0–4 (hr*ng/g) |
574.23 | - | 1,277.7 | - | 2.23 | 0.00001 |