Table 1.
Genes demonstrating similar dimethylK9/K27-H3 states in both stress models
| Genes | Gene activity | Reference |
|---|---|---|
| A | ||
| Aktip/Ft1 | General regulator of apoptosis via PKB/Akt pathway | Remy and Michnick, 2004 |
| Casp14 | Expressed during ischemic neuronal cell death | Krajewska et al., 2004 |
| CD84 | Enhances Ifn-γ secretion during inflammatory responses | Yan et al., 2007 |
| Fcrlb | Involved in cell-mediated cytotoxicity, inflammation, and hypersensitivity | Daëron, 1997 |
| Gstm4 | Reduces oxidative stress damage by inactivating reactive intermediates | Hayes et al., 2005 |
| Ikbkb | Activity allows for activation NfκB-dependent pathways | Schmid and Birbach, 2008 |
| IL-16 | Marker of microglial activation in inflammatory states | Guo et al., 2004 |
| Il1rl1 | Involved in induction and signaling in TNFα, IL-2, IL-6, IL-12, and IL-18 pathways | Subramaniam et al., 2004 |
| IL8rα | Increased expression following inflammatory stimuli (LPS) | Lee et al., 2002 |
| NEDD9 | Implicated in NFκB signaling through Tax | Singh et al., 2007 |
| Sep-15 | Possesses anti-oxidant properties; dysregulation is implicated in neurodegenerative disorders | Chen and Berry, 2003;Ashrafi et al., 2007 |
| SLAM7 | Involved in NK cytotoxity and B-cell activation | Calpe et al., 2008 |
| SLAM9 | Unknown function; homology suggests similar function to SLAM7 | Calpe et al., 2008 |
| B | ||
| Fgd5 | RhoGEF predicted to be involved in actin remodeling via Rac-Pac pathways | Rossman et al., 2005;Buchsbaum, 2007 |
| Sorbs3/vinexin | Involved in cell–cell adhesion and actin dynamics | Kioka et al., 1999 |
| C | ||
| Jdp2/Jundm2 | Binding to c-jun causes transcriptional repression via binding to AP-1 sites; binding to ATF-2 causes transcriptional repression via effects on HDAC3 | Eitoku et al., 2008 |
| Mcm8 | Required for eukaryotic genome replication | Maiorano et al., 2006 |
| Spic | Transcription factor similar to Pu0.1 involved in B-cell development; other transcriptional functions unclear | Bemark et al., 1999 |
| TFIIF | Part of the required core of transcriptional initiation machinery | Thomas and Chiang, 2006 |
A, Genes implicated in cellular inflammation, death, or redox reactions; B, genes implicated in cellular plasticity; C, genes implicated in gene regulation. LPS, Lipopolysaccharide.