Table 2.
Genes | Gene activity | Reference | |
---|---|---|---|
A | |||
⇓ In defeat | ⇑ in isolation | ||
Alox5/5-LO | Catalyzes the first step in leukotriene biosynthesis | Murphy and Gijón, 2007 | |
Etv/ERM | Involved in PKC signaling to CD44 and ICAMs | Larsson, 2006 | |
Ndufa3 | Subunit of NADH:ubiquinone oxireductase | Loeffen et al., 1998 | |
Ndufb5 | Subunit of NADH:ubiquinone oxireductase | Loeffen et al., 1998 | |
Sep-15 | Possesses anti-oxidant properties; dysregulation is implicated in neurodegenerative disorders | Chen and Berry, 2003;Ashrafi et al., 2007 | |
Thap1 | Zinc finger protein; pro-apoptotic factor; also implicated in interactions with chromatin remodeling enzymes | Bessière et al., 2008 | |
⇓ In isolation | ⇑ in defeat | ||
CD5l | Unknown; inflammatory by similarity | ||
Edar | Receptor capable of activating NfκB, JNK, and caspase independent death pathways | Kumar et al., 2001 | |
Gstm4 | Reduces oxidative stress damage by inactivating reactive intermediates | Hayes et al., 2005 | |
Gstm5 | Reduces oxidative stress damage by inactivating reactive intermediates | Hayes et al., 2005 | |
IL-2 | Pro-inflammatory cytokine implicated in depression via activation of degradation pathways for W and 5-HT | Müller and Schwarz, 2007 | |
Klrb1b | Inhibitor of NK cell-mediated cytotoxicity | Calpe et al., 2008;Lanier et al., 1994 | |
B | |||
⇓ In defeat | ⇑ in isolation | ||
Ank3 | Involved in linking spectrin/actin network to the cytoplasmic part of integral membrane proteins; involved in neuronal sodium channel inactivation | Shirahata et al., 2006 | |
Ankra2 | Identified as a binding partner for class II HDACs | Wang et al., 2005 | |
Arhgef9 | Critically involved in neuronal gephyrin clustering and actin dynamics | Harvey et al., 2004 | |
Dctn3 | Smallest subunit of dynactin; involved in dynein transport, spindle formation, chromosomal organization, protein transport | Karki et al., 1998 | |
Dync1li2 | Subunit of dynein; may play roles similar to that for dynactin | Karki et al., 1998 | |
Etv5/ERM | Involved in PKC signaling to allow microfilament rearrangement | Larsson, 2006 | |
Kptn | Actin binding protein involved with cytoskeletal rearrangements in platelets | Bearer and Abraham, 1999 | |
Lasp1 | Actin binding protein involved in cystoskeletal remodeling and extension of cellular outgrowths; contains SH3 domain | Schreiber et al., 1998 | |
C | |||
⇓ In defeat | ⇑ in isolation | ||
Ankra2 | Identified as a binding partner for class II HDACs | Wang et al., 2005 | |
Cxxc1 | Binds to unmethylated CpG regions of DNA; acts as a gene activator | Voo et al., 2000 | |
Ddx28 | RNA helicase; involved in transcription and translation | Abdelhaleem, 2005 | |
Ddx42 | RNA helicase; involved in transcription and translation | Abdelhaleem, 2005 | |
E4f1 | Transcription factor regulated by E1A | Le Cam et al., 2004 | |
EII | Elongation factor of RNA polymerase II | Armache et al., 2005 | |
FoxN3 | Member of fork head/ winged transcription factors | Katoh and Katoh, 2004 | |
Gabpb2 | Transcription factor; capable of binding to purine rich regions of genome | Muller and Schwarz, 2007;Le Cam et al., 2004 | |
Gtf2f2 | General transcription factor; binds to RNA pol II | Armache et al., 2005 | |
Gtf2h3 | Integral member of the TFIIH transcription factor involved in NER | Armache et al., 2005 | |
Lmo4 | Transcription factor with GC rich regions; required for hematopoeisis | Ferreira et al., 2005 | |
Med31 | Part of the mediator complex; involved in the transcription of almost all RNA pol II dependent genes | Guglielmi et al., 2007 | |
Nolc1 | Involved in nucleolar organization and genes transcribed by RNA pol I | Tsai et al., 2008 | |
Pola1 | DNA polymerase | Loeb and Monnat, 2008 | |
Pole | DNA polymerase | Loeb and Monnat, 2008 | |
Rnaseh2a | Ribonuclease; implicated in neuroinflammatory disorders | Rigby et al., 2008 | |
Smad4 | Involved in TGF-β signaling via binding to DNA along with SMAD1 or 2 | Ross and Hill, 2008 | |
Sox12 | Group C Sry-HMG related transcription factor | Dy et al., 2008 | |
Sox17 | Sry-HMG related transcription factor important in early development | Jang and Sharkis, 2007 | |
Sox4 | Group C Sry-HMG related transcription factor | Dy et al., 2008 | |
Sp1 | Transcription factor capable of binding to GC rich domains | Li et al., 2004 | |
Tsen 34 | One of two subunits important for tRNA splicing and pre-mRNA 3′-end formation | Paushkin et al., 2004 | |
⇓ In isolation | ⇑ in defeat | ||
Ints7 | Subunit of the integrator complex which associates with RNA pol II | Nakagawa et al., 2008 | |
Mcm3 | Required for eukaryotic genome replication | Maiorano et al., 2006 | |
Msx2 | Transcriptional repressor of cells derived from the neural crest | Ramos and Robert, 2005 | |
Tmem34 | Possible tumor suppressor gene | Akaishi et al., 2007 |
A, Genes implicated in cellular inflammation, death, or redox reactions; B, genes implicated in cellular plasticity; C, genes implicated in gene regulation. regulation. Up arrows indicate increased pCREB binding. Down arrows indicate decreased pCREB binding. HDAC, Histone deacetylase; HMG, high mobility group; NK, natural killer; NER, nucleotide excision repair; JNK, c-Jun N-terminal kinase.