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. Author manuscript; available in PMC: 2009 Jul 29.
Published in final edited form as: J Hum Lact. 2007 May;23(2):184–190. doi: 10.1177/0890334407300336

Table 1.

Concentrations of Methadone in Breast Milk*

N Range
(ng/mL) 		Mean (ng/mL)
Concentration of
Methadone ± SD 		Mean Infant Dose
Ingestible
(mg/day ± SD)
Day 1 0.006 ± 0.007
     Trough
          Prefeed 7 27.1-179.0 82.3 ± 50.5
          Postfeed 4 31.5-130.5 64.8 ± 45.5
     Peak
          Prefeed 6 63.6-187.5 128.2 ± 51.1
          Postfeed 5 51.7-261.8 144.3 ± 79.6
Day 2 0.018 ± 0.010
     Trough
          Prefeed 10 21.0-217.9 76.1 ± 66.0
          Postfeed 8 20.6-225.1 80.2 ± 76.9
     Peak
          Prefeed 9 27.4-274.6 110.3 ± 80.3
          Postfeed 8 31.6-274.0 125.2 ± 86.6
Day 3 0.039 ± 0.016
     Trough
          Prefeed 12 38.1-241.5 79.5 ± 57.8
          Postfeed 12 42.1-169.5 80.1 ± 40.1
     Peak
          Prefeed 12 45.1-193.3 113.5 ± 46.8
          Postfeed 10 52.3-182.8 123.4 ± 35.0
Day 4 0.084 ± 0.036
     Trough
          Prefeed 12 42.6-229.7 101.8 ± 55.9
          Postfeed 12 49.4-314.2 114.7 ± 84.2
     Peak
          Prefeed 12 79.9-281.4 166.0 ± 67.8
          Postfeed 12 101.5-301.6 199.5 ± 66.7
*

Concentration of methadone in breast milk increased over time for the peak postfeed sampling time (t(22) = 2.40, P = .0255).