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. Author manuscript; available in PMC: 2009 Jul 29.
Published in final edited form as: J Hum Lact. 2007 May;23(2):184–190. doi: 10.1177/0890334407300336

Table 2.

Concentrations of Methadone in Maternal Plasma

N Range
(ng/mL)
Mean (ng/mL)
Concentration of
Methadone ± SD
Day 1
     Trough 12 47.0-409.0 149.4 ± 105.1
     Peak 12 117.0-441.0 253.2 ± 101.0
Day 2
     Trough 12 45.0-247.0 120.4 ± 70.7
     Peak 10 80.0-592.0 343.7 ± 162.6
Day 3
     Trough 12 71.0-352.0 140.9 ± 78.16
     Peak 12 178.0-707.0 337.3 ± 146.6
Day 4
     Trough 12 111.0-384.0 188.2 ± 73.5
     Peak 11 176.0-694.0 414.2 ± 163.3