Fully adjusted models for markers of inflammation and risk for endothelial dysfunction. Displayed are ORs for each quartile compared with first quartile of myeloperoxidase (MPO; left) or C-reactive protein (CRP; right) with endothelial dysfunction defined as flow-mediated dilation less than median. Models include Framingham Risk Score, prevalent cardiovascular disease, cardiovascular medications, and alternative marker of inflammation (C-reactive protein or myeloperoxidase). Myeloperoxidase predicts endothelial dysfunction (P=0.001 for trend), whereas C-reactive protein does not (P=0.87 for trend). *OR, 2.1 (95% CI, 1.02 to 4.5; P=0.04). †OR, 6.4; 95% CI, 2.6 to 16; P<0.001).