Table I.
Baseline characteristics of cases with and controls without EAC
| Clinical parameter | Cases (N = 309) | Controls (N = 275) | P value comparing cases versus controls |
| Gender | |||
| Male | 89% | 88% | 0.62a |
| Female | 11% | 12% | |
| Median age (range) | 64.1 (21–91) | 62.9 (30–96) | 0.49b |
| Median BMIc (range) | 23.3 (15–36) | 22.6 (14–36) | 0.01b |
| Smoking status | |||
| Never smoker | 20% | 31% | 0.01a |
| Ex-smoker | 55% | 50% | |
| Current smoker | 25% | 19% | |
| Median pack-years of ever-smokers (range) | 33.7 (0.2–212) | 30.0 (0.1–218) | 0.21b |
| Caucasian race | 98% | 98% | 0.54a |
| Tumor stage of esophageal cancer | |||
| I | 8% | — | |
| II | 40% | — | |
| III | 25% | — | |
| IV | 27% | — | |
| EGF genotype | |||
| A/A | 33% | 40% | 0.02a |
| A/G | 42% | 44% | |
| G/G | 25% | 16% | |
| GERD frequency | |||
| <1 Mo. (GERD free) | 51% | 77% | <0.001a |
| ≥1/Mo. and ≤1/wk | 27% | 14% | |
| >1/Wk | 22% | 9% | |
| GERD duration | <0.001a | ||
| <1 Year | 34% | 78% | <0.001a |
| ≥1 and ≤15 Years | 32% | 12% | |
| >15 Years | 34% | 10% | |
| Alcohol historyd | |||
| Yes | 94% | 91% | 0.32a |
| No | 6% | 9% |
mo., month; wk, week.
a
Fisher's exact test.
b
t-test/Wilcoxon rank sum test.
c
Median BMI when patients were in their twenties.
d
Alcohol history was only available for 246 cases and 66 controls.