Table II.
OR of the risk of EAC by EGF A61G polymorphism in the overall cohort and in GERD versus GERD-free subsets
| Clinical parameter | Total number of cases/controlsa |
A/G versus A/A |
G/G versus A/A |
||
| OR (95% CI) | P value | OR (95% CI) | P value | ||
| Crude analysis | |||||
| Overall | 309/275 | 1.16 (0.8–1.7) | 0.43 | 1.88 (1.2–3.0) | 0.007 |
| GERD subset | 150/62 | 3.27 (1.6–6.8) | 0.002 | 8.95 (3.6–22.3) | <0.001 |
| GERD-free subset | 159/213 | 0.68 (0.44–1.06) | 0.087 | 0.44 (0.22–0.87) | 0.017 |
| Adjusted analysisb | |||||
| Overall | 309/275 | 1.22 (0.8–1.8) | 0.30 | 1.90 (1.2–3.0) | 0.007 |
| GERD subset | 150/62 | 3.59 (1.7–7.7) | 0.001 | 9.71 (3.8–25.0) | <0.001 |
| GERD-free subset | 159/213 | 0.70 (0.44–1.11) | 0.13 | 0.44 (0.22–0.90) | 0.024 |
OR, odds ratio.
a
[N/n] where N = number of cases and n = number of controls. Overall: A/A [77/44]; A/G [131/122] and G/G [101/109]; total [309/275]; GERD subset: A/A [62/9]; A/G [68/27] and G/G [20/26]; total [150/62] and GERD-free subset: A/A [15/35]; A/G [63/95] and G/G [81/83]; total [159/213].
b
Adjusted for age, gender, smoking status, pack-years and adult BMI.