Table III.
Exploratory adjusteda OR for the joint effects of GERD frequency (A) or duration (B) and EGF A61G polymorphism on EAC risk
| A. GERD frequency | ||||
| EGF genotype | <1/Mo | ≥1/Mo and ≤1/wk | >1/Wk | Marginal OR |
| A/A | 1.00 (81/83)b | 1.51 (0.7–3.3) (19/14) | 0.07 (0.01–0.6) (1/12) | 1.00 |
| A/G | 0.70 (0.4–1.1) (63/95) | 2.78 (1.4–5.4) (41/17) | 3.09 (1.4–6.9) (27/10) | 1.02 (0.7–1.5) |
| G/G | 0.45 (0.2–0.9) (15/35) | 3.05 (1.2–7.7) (22/7) | 21.80 (5.1–94) (40/2) | 1.25 (0.8–2.1) |
| Marginal OR | 1.00 | 2.97 (1.9–4.7) | 3.71 (2.2–6.4) | — |
| B. GERD duration | ||||
| EGF genotype | <1 Year | ≥ 1 and ≤15 Years | >15 Years | Marginal OR |
| A/A | 1.00 (45/83) | 3.99 (1.8–8.9) (27/12) | 4.09 (1.9–8.7) (29/14) | 1.00 |
| A/G | 0.94 (0.56–1.58) (46/95) | 5.02 (2.5–10) 44/16 | 8.25 (3.7–18) (39/10) | 1.14 (0.8–1.7) |
| G/G | 0.69 (0.32–1.45) (13/35) | 8.62 (3.3–23) (28/6) | 22.39 (6.5–78) (36/3) | 1.38 (0.8–2.3) |
| Marginal OR | 1.00 | 5.57 (3.5–8.9) | 8.11 (4.9–13) | — |
mo, month; wk, week.
a
Adjusted for age, gender, smoking status, pack-years and adult BMI.
b
[N/n] where N = number of cases and n = number of controls.