Table III.
Level of FW-induced DNA strand breaks, EndoIII- and FPG-sensitive sites in Caco2 cells measured with the comet assay (a) PM diet versus VEG diet (n = 16); (b) RM diet versus VEG diet (n = 12) (unadjusted means, comparison within studies)
Mean | SE | Mean | SE | Mean | SE | |
(a) | Control slides | PM | VEG | |||
Strand breaks (AU) | 113 | 3 | 164 | 13 | 206* | 17 |
EndoIII sites (AU) | 8 | 2 | 24 | 5 | 26 | 6 |
FPG sites (AU) | 25 | 5 | 39 | 8 | 42 | 7 |
(b) | Control slides | RM | VEG | |||
Strand breaks (AU) | 113 | 3 | 167 | 13 | 196* | 15 |
EndoIII sites (AU) | 8 | 2 | 9 | 4 | 15 | 6 |
FPG sites (AU) | 25 | 5 | 24 | 6 | 28 | 4 |
AU, arbitrary units; PM, processed (nitrite-preserved red) meat. P value for paired Students’ t-test of meat versus VEG, *P < 0.05. Control slides were incubated with phosphate-buffered saline and represent the level of background DNA strand breaks.