Table III.
Logistic regression analysis examining the association of chromosome 9p-short telomere length and breast cancer risk
| 9p-short RTL (%) | Cases/controls | ORa (95% CI) | P | ORb (95% CI) | P |
| All subjects | |||||
| ≥Median (≥0.583) | 41/81 | 1.00 | 1.00 | ||
| <Median (<0.583) | 99/78 | 2.53 (1.56–4.12) | <0.001 | 2.58 (1.54–4.33) | <0.001 |
| Long (≥0.680) | 10/41 | 1.00 | 1.00 | ||
| Short (<0.680) | 130/118 | 5.08 (2.35–10.96) | <0.001 | 4.43 (1.98–9.88) | <0.001 |
| By quartiles | |||||
| Q4 (≥0.680) | 10/41 | 1.00 | 1.00 | ||
| Q3 (0.583–0.680) | 31/40 | 3.43 (1.44–8.19) | 3.00 (1.20–7.45) | ||
| Q2 (0.494–0.583) | 35/40 | 3.93 (1.66–9.29) | 3.87 (1.58–9.49) | ||
| Q1 (≤0.494) | 64/38 | 7.51 (3.25–17.37) | <0.001c | 6.62 (2.75–15.94) | <0.001c |
| Premenopausal women | |||||
| ≥Median (≥0.583) | 17/38 | 1.00 | 1.00 | ||
| <Median (<0.583) | 39/29 | 3.00 (1.42–6.35) | 0.004 | 2.80 (1.28–6.16) | 0.010 |
| Long (≥0.680) | 5/18 | 1.00 | 1.00 | ||
| Short (<0.680) | 51/49 | 3.91 (1.34–11.45) | 0.013 | 3.62 (1.18–11.08) | 0.024 |
| By quartiles | |||||
| Q4 (≥0.680) | 5/18 | 1.00 | 1.00 | ||
| Q3 (0.583–0.680) | 12/20 | 2.29 (0.67–7.85) | 2.16 (0.60–7.83) | ||
| Q2 (0.494–0.583) | 11/14 | 2.90 (0.81–10.35) | 2.87 (0.76–10.81) | ||
| Q1 (≤0.494) | 28/15 | 6.99 (2.14–22.83) | <0.001c | 6.16 (1.78–21.32) | 0.002c |
| Postmenopausal women | |||||
| ≥Median (≥0.583) | 22/42 | 1.00 | 1.00 | ||
| <Median (<0.583) | 53/47 | 2.08 (1.09–3.99) | 0.027 | 2.41 (1.20–4.87) | 0.014 |
| Long (≥0.680) | 4/22 | 1.00 | 1.00 | ||
| Short (<0.680) | 71/67 | 5.89 (1.91–18.14) | 0.002 | 5.66 (1.75–18.28) | 0.004 |
| By quartiles | |||||
| Q4 (≥0.680) | 4/22 | 1.00 | 1.00 | ||
| Q3 (0.583–0.680) | 18/20 | 5.21 (1.49–18.18) | 4.32 (1.15–16.26) | ||
| Q2 (0.494–0.583) | 21/26 | 4.60 (1.36–15.49) | 5.13 (1.45–18.13) | ||
| Q1 (≤0.494) | 32/23 | 8.24 (2.46–27.66) | 0.002c | 7.53 (2.11–26.79) | 0.003c |
Bold numbers are statistically significant.
a
OR adjusted for age as continuous and race.
b
OR adjusted for age as continuous, race, smoking status (never/ever), alcohol use (never/ever), education, family history of cancer (no/yes), hormone replacement therapy (no/yes), history of pregnancy (no/yes), menopausal status (when appropriate) and physical activity in teens (no/yes).
c
P for trend.