Figure 3.

Overlay of amino- and carboxyl-terminal domains of eIF4A onto the equivalent domains of other helicases. The amino-terminal domain of eIF4A is in approximately the same orientation as in Fig. 2. The color convention for the domains and conserved motifs of eIF4A is the same as in Fig. 2. In all cases, the “target” helicase is shown as a transparent tube drawing against the solid eIF4A model. Oligonucleotides are shown as CPK space-filling models. (A) PcrA DNA helicase (PDB ID code 3PJR) with ATP and the single-stranded portion of the DNA. ATP is shown as a ball-and-stick representation. (B) HCV RNA helicase with ssDNA (PDB ID code 1A1V). (C) UvrD DNA helicase (PDB ID code 1D9X).