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. 2009 Aug 5;97(3):897–905. doi: 10.1016/j.bpj.2009.05.033

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Calculated k_on values and the role of electrostatics. Results from SMOL and PNP methods are shown in panels A and B. In these calculations, the diffusing particle ACh was assigned a unit positive charge. (C) SMOL-calculated k_on with the charge on ACh turned off. (D) The electrostatic guidance enhancement factor (EGF) calculated as the ratio of the tetramer k_on values shown in panels A and C. Eleven structural models (the initial model plus 10 snapshots from MD simulation) were used. (Open circles) Subunit 1; (cross) subunit 2; (triangle) subunit 3; and (solid circles) subunit 4.