Figure 4.

Oligomer size distribution comparison between an unresolved β-amyloid(1–40) sample and a gel filtration chromatography separated monomer/dimer sample (the inset presents the same data shown in Fig. 2, shown here for convenience). The monomer/dimer fraction was deposited onto a cover glass immediately after it was collected from the column. The SMS approach revealed significant contributions from larger oligomers compared to those separated by HPLC. Further analysis below shows improved quantitative analysis for the SMS data.