Figure 6.
PCer-induced alterations in the membrane physical properties of raft mixtures. Fluorescence anisotropy of (A) (▪,□) t-PnA, and (B) (▴,▵) Rho-DOPE and (•,○) NBD-DPPE in the absence of SMase (solid symbols) and 2 h after SMase addition (open symbols). The mean fluorescence lifetimes of (C) t-PnA and (D) NBD-DPPE are shown (the symbols are the same as in A and B, respectively). The values are the means of at least three independent experiments. The SD was always lower than (A and B) 0.01, (C) 2 ns for t-PnA, and (D) 0.5 ns for NBD-DPPE.