Figure 4.

MiRNA expression changes in response to UV treatment. (A) Heatmap of differentially expressed miRNAs (P<0.01; −1.5>fold change>1.5) 4 and 24 h after UVC irradiation (8 J/m²) in primary human fibroblasts. (B) Many differentially regulated miRNAs in primary human fibroblasts are also regulated in HeLa cells after UVC treatment (8 J/m²). (C) Dependence of miRNA regulation on ATM/ATR activity. Cells were treated with 8 mM caffeine 4 h before UVC exposure. After UV treatment cells were recovered in medium containing caffeine for 4 h.