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Blockade of aromatase function leads to loss of pregnancy. Pregnant mice (d 5 morning) were ovariectomized and treated with exogenous P in combination with or without letrozole, an aromatase inhibitor (AI). The uteri were collected on d 10 of gestation (D10). The sections of d 10 uteri treated with P only (Day10-P) or P and AI (D10-P+AI) were analyzed with eosin and hematoxylin stain. E, AM, and M denote embryo, anti-mesometrial area, and mesometrial area, respectively.
