Fig. 1.

Schematic diagram of the experimental design. Spinal cord injury in rats was inflicted by a weight-drop impact (10 g weight dropped from a height of 12.5 mm at T11–T12). Vehicle or BBG at 10 or 50 mg/kg was administered intravenously right after injury and once daily on days 2 and 3. Motor function was evaluated in a first group of rats from days 1–42. Tissue injury was evaluated on longitudinal sections of spinal cord prepared at day 42. Acute inflammatory responses were quantified in a second group of rats processed for immunohistochemistry at day 4.