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. 2009 Jul 15;106(30):12530–12535. doi: 10.1073/pnas.0804273106

Fig. 4.

Fig. 4.

Microglial MT1-MMP mediates increased tumor size. (A) Invasion of glioma cells within organotypic brain slice cultures was determined from MT1-MMP WT (MT1-MMP+/+), MT1-MMP heterozygous (MT1-MMP+/−), and knockout (MT1-MMP−/−) mice 5 d after tumor injection. It is evident that the tumor invasion promoting MT1-MMP activity stems from the parenchyma. Defining the tumor size in organotypic brain slice cultures from MT1-MMP+/+ as 100%, the average tumor size from MT1-MMP−/− mice was 46% and that from MT1-MMP+/+ was 57.5%. (B) The tumor size from MT1-MMP+/− mice was defined as 100% and microglia depletion resulted in a tumor size of 45%. Tumor size of control and microglia-depleted organotypic brain slice cultures containing from MT1-MMP−/− mice was 43% and 16%, respectively. Significance was accessed by Wilcoxon signed-rank test; **P < 0.01.