TABLE 2.

Clinical evaluation used to identify affection status

	Consensus Affection Status
	Unaffected	Possible	Probable	Definite
Clinical Evaluation	(n = 360)	(n = 44)	(n = 231)	(n = 78)
Medical record*	14 (3.9)	5 (11.4)	22 (9.5)	6 (7.7)
Clinical history, DLCO, and CXR†	281 (78.1)	21 (47.7)	16 (6.9)§	0
Clinical history, DLCO, and HRCT scan‡	64 (17.8)	18 (40.9)	191 (82.7)||	0
Surgical lung biopsy	0	0	0	56 (71.8)
Autopsy	1 (0.3)	0	2 (0.9)	16 (20.5)

Definition of abbreviations: CXR = chest radiograph; HRCT = high-resolution computed tomography; DL_CO = carbon monoxide diffusing capacity.

Nine patients had an indeterminate consensus diagnosis and are not included. Percentages are shown in parentheses.

^*“Medical record” represents review of clinical evaluations, radiology reports, autopsy reports, archived lung biopsy slides, and pathology reports. These records were jointly reviewed by study investigators (M.P.S. and D.A.S.) and independently classified on the basis of the best available evidence.

^†Fifty-three patients did not have a DL_CO measurement, and 1 patient had surgical lung biopsy indicating interstitial lung disease (ILD) by report; however, we were unable to locate and review the biopsy material.

^‡Eighteen patients did not have a DL_CO measurement.

^§Nine patients had extensive bilateral, basilar, and peripheral honeycombing on CXR with low lung volumes and DL_CO less than 50% predicted, and seven patients had bilateral, basilar, and peripheral honeycombing on CXR with low lung volumes but without a DL_CO available.

^||Fourteen subjects had a surgical lung biopsy indicating ILD by report; however, we were unable to locate and review the biopsy.