Figure 3.

Cross-sectional z scores of height-adjusted maximal expiratory flows at ages 2.4 mo and 6, 11, and 16 yr for the preschool wheeze phenotypes. The preschool wheeze phenotypes were defined as follows: no wheeze from birth to age 6 yr (never wheeze), wheezing LRI before age 3 yr only (transient early wheeze), wheeze at age 6 yr only (late-onset wheeze), and wheezing LRI before age 3 yr and wheeze at age 6 yr (persistent wheeze). One-way analysis of variance with Bonferroni's multiple comparison test was used to assess differences between groups. Sample sizes for each of the preschool wheeze phenotypes (never wheeze, transient early wheeze, late-onset wheeze, and persistent wheeze) were as follows: at 2.4 mo, n = 67, 21, 21, and 16; at age 6 yr, n = 260, 104, 81, and 81; at age 11 yr, n = 266, 113, 84, and 78; and at age 16 yr, n = 206, 91, 69, and 56, respectively. *p < 0.001 compared with never wheeze; ^†p = 0.03 compared with never wheeze; ^‡p = 0.002 compared with never wheeze; ^δp = 0.02 compared with never wheeze.