TABLE 1.

SKIN TEST REACTIVITY AND TOTAL SERUM IgE LEVELS AT AGES 11 AND 16 yr FOR PRESCHOOL WHEEZE PHENOTYPES

	Skin Test Reactivity†				Total Serum IgE (IU/ml)¶
	Age 11 yr		Age 16 yr		Age 11 yr		Age 16 yr
Preschool Wheeze Phenotype*	n	% Pos (95% CI)	n	% Pos (95% CI)	n	GM (95% CI)	n	GM (95% CI)
Never wheeze	299	51.2 (45–57)	228	68.4 (62–74)	252	45 (35–57)	168	63 (49–83)
Transient early wheeze	126	51.6 (43–61)	96	62.5 (52–72)	114	56 (42–78)	74	58 (40–83)
Late-onset wheeze	97	64.9 (55–74)‡§	75	78.7 (68–87)§	83	109 (74–158)**	61	96 (66–138)
Persistent wheeze	87	63.2 (52–73)‡	62	85.5 (74–93)‡§	73	93 (59–148)**	49	83 (51–132)
p Value		0.04‖		0.006‖		0.001††		0.2††

Definition of abbreviations: CI = confidence interval; GM = geometric mean; Pos = positive.

^*Preschool wheeze phenotypes were defined as follows: no wheeze from birth to age 6 yr (never wheeze), wheezing LRI before age 3 yr only (transient early wheeze), wheeze at age 6 yr only (late-onset wheeze), and wheezing LRI before age 3 yr and wheeze at age 6 yr (persistent wheeze).

^†Skin test positive (Pos) was defined as at least one positive skin test (wheal, ⩾ 3 mm sum of the orthogonal diameters) to any of the six local aeroallergens tested.

^‡p < 0.05 compared with never wheezers by Pearson 2 × 2 χ² analysis.

^§p < 0.05 compared with transient early wheezers by Pearson 2 × 2 χ² analysis.

^‖p Value based on Pearson χ² statistic with 3 degrees of freedom.

^¶Total serum IgE was normally distributed after log base 10 transformation; geometric means and 95% confidence intervals are presented as international units per milliliter.

^**p < 0.05 compared with never wheezers by Bonferroni's multiple comparison test.

^††p Value based on one-way analysis of variance.