TABLE 1.
BASELINE CHARACTERISTICS OF COHORT
| Variable | All Participants (n = 3,075) | Hospitalized for CAP (n = 161) | Not Hospitalized for CAP (n = 2,914) | p Value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age | 73.6 ± 2.9 | 73.7 ± 2.8 | 73.6 ± 2.6 | 0.5 |
| Sex, % males | 48.5 | 55.9 | 48.1 | 0.05 |
| Race, % Blacks | 41.7 | 35.4 | 42 | 0.1 |
| Site, % Memphis | 50.3 | 46 | 51 | 0.3 |
| Comorbid conditions | ||||
| Congestive heart failure, % | 3.1 | 6.3 | 2.9 | 0.007 |
| Coronary heart disease, % | 20.8 | 30.1 | 20.3 | 0.0003 |
| Diabetes, % | 15.3 | 22.6 | 14.9 | 0.008 |
| Serum creatinine, mg/dl | 1.06 ± 0.17 | 1.17 ± 0.5 | 1.06 ± 0.15 | 0.048 |
| FEV1, % predicted | ||||
| FEV1 ⩾ 80% | 70.7 | 50.9 | 71.8 | < 0.0001 |
| 80% > FEV1 > 50% | 19.2 | 24.3 | 18.9 | < 0.0001 |
| FEV1 ⩽ 50% | 10.1 | 24.8 | 9.3 | < 0.0001 |
| Hypothyroidism, % | 7.4 | 10.1 | 7.2 | 0.4 |
| Smoking | ||||
| Current | 10.4 | 17.5 | 10 | < 0.0001 |
| Past | 45.7 | 54 | 45.2 | |
| Pack-yr of smoking | 19.1 ± 28 | 27.5 ± 32 | 18.6 ± 27 | < 0.0001 |
| Inflammatory markers* | ||||
| TNF, pg/ml | 3.2 (2.4–4.1) | 3.6 (2.7–4.9) | 3.2 (2.4–4.1) | < 0.0001 |
| IL-6, pg/ml | 1.8 (1.3–2.8) | 2.6 (1.7–3.5) | 1.8 (1.2–2.7) | < 0.0001 |
| CRP, mg/L | 1.7 (1–3) | 2.1 (1.2–3.8) | 1.6 (1–3) | 0.002 |
| Pneumococcal vaccination, % | 29.1 | 30.1 | 29 | 0.8 |
| Nutritional markers | ||||
| Weight, kg | 75.8 ± 15 | 75.5 ± 15.1 | 75.8 ± 15 | 0.8 |
| BMI, kg/m2 | 27.4 ± 4.8 | 26.9 ± 5.8 | 27.4 ± 4.9 | 0.2 |
| Serum albumin, g/dl | 4 ± 0.3 | 4 ± 0.4 | 4 ± 0.3 | 0.5 |
| Lean body mass, kg | 47.5 ± 10.1 | 48.4 ± 10.1 | 47.5 ± 10.1 | 0.2 |
| Medications, % | ||||
| Oral steroids | 2.3 | 5.4 | 2.1 | 0.02 |
| Aspirin | 37.4 | 38.3 | 37.4 | 0.8 |
Definition of abbreviations: BMI = body mass index; CAP = community-acquired pneumonia; CRP = C-reactive protein; TNF = tumor necrosis factor.
Values are expressed as mean ± SD.
*
Expressed as median with interquartile range.