TABLE 4.
ADJUSTED RISK ACCORDING TO NUMBER OF INFLAMMATORY MARKERS IN THE HIGHEST TERTILE FOR ALL PARTICIPANTS AND STRATIFIED BY FEV1, SMOKING STATUS, AND COMORBID CONDITIONS
| Variable | Neither Inflammatory Marker in Tertile 3 | At Least One Inflammatory Marker in Tertile 3 | Both Inflammatory Markers in Tertile 3 |
|---|---|---|---|
| All participants | Referent | 1.6 (1.1–2.3) | 2.8 (1.8–4.3)† |
| Stratified by FEV1 | |||
| FEV1 ⩽ 50% (n = 269)* | 2.8 (1.3–6.4) | 6.3 (3.3–11.9) | 6.8 (2.9–16) |
| FEV1> 50% (n = 1,949) | Referent | 1.4 (0.8–2.3) | 2.5 (1.4–4.7) |
| Stratified by smoking status | |||
| Ever smoked (n = 1,140)* | 1.1 (0.6–2.2) | 2.7 (1.5–5) | 3.5 (1.7–7.1) |
| Never smoked (n = 1,015) | Referent | 0.9 (0.4–2.1) | 2.2 (0.9–5.4) |
| Stratified by diabetes | |||
| Diabetes (n = 313)* | 1.4 (0.5–3.6) | 2.2 (1–4.7) | 5.2 (2.4–11.7) |
| No diabetes (n = 1,846) | Referent | 1.8 (1.1–3) | 2.4 (1.3–4.5) |
| Stratified by comorbid conditions | |||
| Two or more comorbid conditions (n = 234)* | 2.5 (0.8–7.6) | 4 (1.8–8.9) | 8.1 (3.6–18.1) |
| One comorbid conditions (n = 627) | 1.9 (0.9–3.9) | 3.6 (1.9–6.9) | 4 (1.8–9.1) |
| No comorbid conditions (n = 1,298) | Referent | 1.3 (0.7–2.7) | 1.6 (0.6–4.5) |
Values adjusted for age, race, sex, and site. Comorbid conditions include history of congestive heart failure, coronary artery disease, FEV1 ⩽ 50% predicted, serum creatinine > 1.5mg/dl, and diabetes.
*
Numbers do not add to 3,075 due to missing data for inflammatory marker or covariates.
†
p Value for the interaction between risk of community-acquired pneumonia for tumor necrosis factor (TNF) tertile 3, interleukin (IL)-6 tertile 3, and the combination of TNF and IL-6 in tertile 3 was 0.01.