Figure 10.

Effects of the toll-like receptor 4 antagonist E5564. All mice received Etx + OA and either a placebo (Plcb) or E5564, 30 minutes before endotoxin. (A) Twenty-four-hour survival rates. The trend in improved survival in the E5564 group was not statistically significant (p = 0.36). (B) Lung weights. Lung weights after Etx + OA were lower in the E5564 group, indicating less pulmonary edema. Horizontal bar indicates normal range in lung weight (from Figure 1). (C) MPO activity. MPO activity was lower in the E5564 group, indicating less neutrophil recruitment to the lungs. Horizontal bar indicates normal range in MPO (from Figure 7B). *p < 0.05 compared with the Plcb group.